Huddlestone was dismissed by referee Paul Tierney with 17 minutes of the game to go and with the scoreline at 1-0 after a sliding tackle on Idrissa Gana Gueye, making contact with his left leg.
This was the eighth card that the midfielder has picked up in a match in all competitions this season (seven yellows, one red), adding to the joint-worst disciplinary record at the club along with Sam Clucas.
It was the 60th card that a Hull player has received this campaign in just their 37th game in league and cup fixtures.
This will result in a three-match suspension, meaning that the midfielder misses key matches against West Ham and Middlesbrough, who are both in the bottom half of the table and targets for Hull to find points for league survival.
The last game of the ban is an away fixture against Pep Guardiola’s Manchester City on April 8. Should he remain fit, he will next be available for selection for their trip to Stoke on April 15.